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Biotheus Out-licenses ex-China BiSpecific Rights to BioNTech in $1 Billion Deal

publication date: Nov 6, 2023

Zhuhai’s Biotheus sold ex-China rights for a bispecific antibody candidate to BioNTech for $55 million upfront and a milestone package of more than $1 billion, plus royalties. The candidate, PM8002, is made up of humanized anti-PD-L1 single heavy-chain variable (VHH) domains fused to an anti-VEGF-A IgG1 antibody containing Fc-silencing mutations. It is currently being tested in China Phase II trials to test its efficacy and safety as a monotherapy or in combination with chemotherapy in advanced solid tumors patients. The agreement was BioNTech's fifth in-licensing with a China biopharma this year.. More details....

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