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CASI Pharma Acquires VCP/p97 Inhibitor for Myeloid Leukemia and MDS

publication date: Jul 21, 2023

CASI Pharmaceuticals, a China in-licensing company with operations in Beijing and Maryland, has acquired global rights to a novel VCP/p97 inhibitor from Cleave Therapeutics. CB-5339, which has completed a US Phase I trial in acute myeloid leukemia and myelodysplastic patients, is an oral small molecule valosin-containing protein (VCP)/p97 inhibitor, designed to disrupt protein homeostasis, DNA damage response and other cellular stress pathways. CASI will assume all responsibility for Cleave’s US IND for CB-5339 along with global intellectual property rights. Cleave also announced it is selling its preclinical assets to Eikon Therapeutics. More details....

Stock Symbol: (NASDAQ: CASI)

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