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CellOrigin Starts China Trial of Macrophage-based CAR Therapy

publication date: Dec 21, 2023

CellOrigin Biotechnology (Hangzhou) announced a solid-tumor patient was dosed in a China trial of SY001, the first China trial of a CAR-macrophage therapy. The company develops immune cell therapies (such as macrophages, NK cells) derived from genetically engineered pluripotent stem cells (iPSC) for solid tumor cancers. It believes the unique characteristics of macrophages allow the drug to infiltrate the solid tumor microenvironment. In the first two patients, SY001 was well tolerated with no dose-limiting toxicity. The investigator-led study is enrolling patients with advanced solid tumors. More details....

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