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Connect Plans to Partner Ulcerative Colitis Candidate After Disappointing Trial

publication date: May 5, 2022

Connect Biopharma, a Taicang-San Diego inflammatory disease company, reported disappointing results from a US Phase II trial of an S1P inhibitor in patients with ulcerative colitis. Connect said it will look for a partner to take over further clinical trials of the drug. In the trial, CBP-307 did not provide a statistically significant improvement over other S1P inhibitors. CBP-307 is an oral small molecule designed to modulate sphingosine 1-phosphate receptor 1. Connect’s lead candidate, CBP-201, is an antibody that targets interleukin-4 receptor alpha IL-4Rα currently in a Phase III trial for atopic dermatitis and asthma. More details....

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