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DualityBio and BioNTech to Begin Phase III US Trial of ADC for Breast Cancer

publication date: Sep 1, 2023

Duality Biologics (Suzhou), together with its partner BioNTech, will start a US Phase III trial of DB-1303, a topoisomerase-1 inhibitor-based ADC directed against HER2 breast cancer. Earlier this year, Duality out-licensed global rights (ex-China) for DB-1303 to BioNTech in a $1.5 billion deal. DB-1303 targets breast cancer patients with low levels of HER2, a level previously considered HER2 negative. The candidate addresses the same indication as Enhertu, an AstraZeneca- Daiichi Sankyo drug that posted sales of $1.6 billion in 2022. However, the Duality-BioNTech candidate may demonstrate greater safety. More details....

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