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Hengrui Launches Antifungal in China for Vulvovaginal Candidiasis

publication date: Feb 9, 2024

Jiangsu Hengrui Pharma announced a China launch for Vivjoa® (oteseconazole) in China, a novel oral azole antifungal approved to treat severe vulvovaginal candidiasis (VVC). In a China Phase III trial, the 2-day oral regimen of Vivjoa showed superior efficacy to the previous standard-of-care, fluconazole, in women presenting with severe VVC. Oteseconazole selectively inhibits fungal CYP51, which is required for fungal cell wall integrity. Because of its chemical structure, oteseconazole has a lower affinity for human CYP enzymes than fungal CYP enzymes. In 2019, Hengrui acquired China rights to Vivjoa from Mycovia Pharma of North Carolina. More details....

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