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Legend Signs $1.2 Billion Agreement Selling Global Rights for DLL3 CAR-T to Novartis

publication date: Nov 13, 2023

Legend Biotech (NASDAQ: LEGN), a New Jersey-Nanjing CAR-T biotech, partnered its DLL3 (delta-like ligand 3) CAR-T candidates to Novartis in a $1.2 billion agreement ($100 million upfront). Legend will start a US trial of LB2102 in patients with extensive stage small cell lung cancer and large cell neuroendocrine carcinoma. Novartis will own worldwide rights to develop, manufacture and commercialize the DLL3 group of cell therapies, and it may use its T-Charge™ platform to manufacture the candidates. In 2017, Legend, then a Genscript subsidiary headquartered in Nanjing, stunned the world when its BCMA CAR-T produced a better than 90% response in pretreated multiple myeloma patients. More details....

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